abstract：:The influence of alpha2-autoreceptors on the facilitation of [3H]-noradrenaline release mediated by angiotensin II was studied in prostatic portions of rat vas deferens preincubated with [3H]-noradrenaline. Angiotensin II enhanced tritium overflow evoked by trains of 100 pulses at 8 Hz, an effect that was attenuated b...

journal_title：Neurochemistry international

authors： Talaia C,Queiroz G,Pinheiro H,Moura D,Gonçalves J

更新日期：2006-12-01 00:00:00

abstract：:Apart from acetyl-choline (Ach), adenosine-5'-trisphosphate (ATP) is thought to play a role in neuromuscular function, however little information is available on its cellular physiology. As such, effects of ATP and adenosine on contractility of mice diaphragmatic and skeletal muscles (m. extensor digitorum longa-MEDL)...

journal_title：Neurochemistry international

authors： Grishin SN,Teplov AY,Galkin AV,Devyataev AM,Zefirov AL,Mukhamedyarov MA,Ziganshin AU,Burnstock G,Palotás A

更新日期：2006-12-01 00:00:00

abstract：:The inflammatory central nervous system response that involves activated microglia and reactive astrocytes may both heal and harm neurons, as inflammatory mediators lead to neuroprotection or excitation at one dose but to injury at a different concentration. To investigate these complex cellular interactions, L-trans-...

journal_title：Neurochemistry international

authors： de Yebra L,Malpesa Y,Ursu G,Pugliese M,Liévens JC,Kerkerian-Le Goff L,Mahy N

更新日期：2006-12-01 00:00:00

abstract：:Maple syrup urine disease (MSUD) is an inherited neurometabolic disorder biochemically characterized by the accumulation of the branched-chain alpha-keto acids (BCKA) alpha-ketoisocaproic (KIC), alpha-keto-beta-methylvaleric (KMV) and alpha-ketoisovaleric (KIV) and their respective branched-chain alpha-amino acids in ...

journal_title：Neurochemistry international

authors： Funchal C,Latini A,Jacques-Silva MC,Dos Santos AQ,Buzin L,Gottfried C,Wajner M,Pessoa-Pureur R

更新日期：2006-12-01 00:00:00

abstract：:The amyloid beta-peptide (AbetaP) is the major protein component of brain senile plaques in Alzheimer's disease. The redox state of methionine-35 residue plays a critical role in peptide neurotoxic actions. We used the fragment 31-35 of AbetaP [AbetaP(31-35)], containing a single methionine-35 residue (Met-35), to inv...

journal_title：Neurochemistry international

authors： Misiti F,Clementi ME,Tringali G,Vairano M,Orsini F,Pezzotti M,Navarra P,Giardina B,Pozzoli G

更新日期：2006-10-01 00:00:00

abstract：:Previously we have demonstrated the presence of presynaptic nicotinic acetylcholine receptors on the terminals of myenteric neurons in Auerbach's plexus of guinea-pig ileum. During these studies we observed, that the presence of hemicholinium-3, an inhibitor of the high affinity choline uptake significantly influences...

journal_title：Neurochemistry international

authors： Mandl P,Kiss JP

更新日期：2006-09-01 00:00:00

abstract：:Alpha-synuclein (ASN), a 140-amino acid protein, is richly expressed in presynaptic terminals in the central nervous system, where it plays a role in synaptic vesicle function. However, if it is altered and accumulated it is involved in neurodegeneration as Parkinson's disease (PD). ASN contained 35-amino acid domain ...

journal_title：Neurochemistry international

authors： Adamczyk A,Kaźmierczak A,Strosznajder JB

更新日期：2006-09-01 00:00:00

abstract：:The ubiquitin proteasome system (UPS) is a major cellular protein degradation pathway that involves the modulation of key proteins controlling inflammation, cell cycle regulation and gene expression. Modulation of the UPS with proteasome inhibitors has indicated efficacy in the treatment of several disease states incl...

journal_title：Neurochemistry international

authors： Williams AJ,Dave JR,Tortella FC

更新日期：2006-07-01 00:00:00

abstract：:Neurosteroids are modulators of several receptors and ion channels and are implicated in the pathophysiology of several neuropsychiatric diseases including hepatic encephalopathy (HE). The neurosteroid, allopregnanolone, a positive allosteric modulator of GABA(A) receptors, accumulates in the brains of HE patients whe...

journal_title：Neurochemistry international

authors： Ahboucha S,Coyne L,Hirakawa R,Butterworth RF,Halliwell RF

更新日期：2006-06-01 00:00:00

abstract：:L-serine-O-sulphate is a member of a group of amino acids collectively called gliotoxins and is a substrate for the high affinity sodium-dependent glutamate transporters. Previous studies have shown that it is toxic to primary cultures of astrocytes but the mode of toxicity is unknown. The current study demonstrates t...

journal_title：Neurochemistry international

authors： Brennan L,Alves PM,Hewage C,Malthouse JP,McBean GJ

更新日期：2006-06-01 00:00:00

abstract：:The mechanisms of intracellular calcium store depletion and store-related Ca(2+) dysregulation in relation to apoptotic cell death in PC12 cells were investigated at physiological temperatures with a leak-resistant fluorescent indicator dye Fura-PE3/AM by a cooled CCD imaging analysis system. Electron microscopic obse...

journal_title：Neurochemistry international

authors： Yoshida I,Monji A,Tashiro K,Nakamura K,Inoue R,Kanba S

更新日期：2006-06-01 00:00:00

abstract：:Brain edema and the subsequent increase in intracranial pressure are the major neurological complications in fulminant hepatic failure (FHF). Brain edema in FHF is predominantly "cytotoxic" due principally to astrocyte swelling. It is generally believed that ammonia plays a key role in this process, although the mecha...

journal_title：Neurochemistry international

authors： Jayakumar AR,Rao KV,Murthy ChR,Norenberg MD

更新日期：2006-05-01 00:00:00

abstract：:Glucose is the preferred energy substrate for the adult brain. However, during periods of fasting and consumption of a high fat, low carbohydrate (ketogenic) diet, ketone bodies become major brain fuels. The present study was conducted to investigate how the ketogenic diet influences neuronal-glial interactions in ami...

journal_title：Neurochemistry international

authors： Melø TM,Nehlig A,Sonnewald U

更新日期：2006-05-01 00:00:00

abstract：:Exposure to high levels of manganese (Mn) results in a neurological disorder, termed manganism, which shares a similar phenotype to Parkinson's disease due to the involvement of the basal ganglia circuitry in both. The initial symptoms of manganism are likely due to the involvement of the globus pallidus, a region ric...

journal_title：Neurochemistry international

authors： Fitsanakis VA,Au C,Erikson KM,Aschner M

更新日期：2006-05-01 00:00:00

abstract：:Fatty acids play a critical role in brain function but their specific role in the pathophysiology of Parkinson disease (PD) and levodopa-induced motor complications is still unknown. From a therapeutic standpoint, it is important to determine the relation between brain fatty acids and PD because the brain fatty acid c...

journal_title：Neurochemistry international

authors： Julien C,Berthiaume L,Hadj-Tahar A,Rajput AH,Bédard PJ,Di Paolo T,Julien P,Calon F

更新日期：2006-04-01 00:00:00

abstract：:Microglial activation has been implicated in neurodegenerative diseases. Therefore, inhibition of inflammation mediated by microglia is a strategy in neurodegenerative disease therapy. In this study, we isolated cryptotanshinone and 15,16-dihydrotanshinone I from Salvia miltiorrhiza, a traditional Korean herb medicine...

journal_title：Neurochemistry international

authors： Lee P,Hur J,Lee J,Kim J,Jeong J,Kang I,Kim SY,Kim H

更新日期：2006-01-01 00:00:00

abstract：:One hour of ischemia significantly increased protein S100B release from rat brain slices without altering lactate dehydrogenase leakage. Reoxygenation of the ischemic slices, however, increased the levels of these biochemical markers in the medium. Although removal of extracellular Ca(+2) ions from the medium did not ...

journal_title：Neurochemistry international

authors： Büyükuysal RL

更新日期：2005-12-01 00:00:00

abstract：:Superfused rat cerebral cortex slices were submitted to a continuous electrical (5 Hz) stimulation and treated with sodium azide (1-10 mM) in the presence of 2 mM 2-deoxyglucose ("chemical ischemia"). Presynaptic cholinergic activity, evaluated as acetylcholine release, was inhibited depending on the sodium azide conc...

journal_title：Neurochemistry international

authors： Cavallini S,Marti M,Marino S,Selvatici R,Beani L,Bianchi C,Siniscalchi A

更新日期：2005-12-01 00:00:00

abstract：:We investigated whether alterations in glutamate metabolising glutamine synthetase activity occur in human epileptic neocortex, as shown previously for human epileptic hippocampus [Eid, T., Thomas, M.J., Spencer, D.D., Rundén-Pran, E., Lai, J.C.K., Malthankar, G.V., Kim, J.H., Danbolt, N.C., Ottersen, O.P., de Lanerol...

journal_title：Neurochemistry international

authors： Steffens M,Huppertz HJ,Zentner J,Chauzit E,Feuerstein TJ

更新日期：2005-11-01 00:00:00

abstract：:Adenosine is a neuromodulator that can control brain damage through activation of A(1), A(2A) and A(3) receptors, which are located in both neurons and other brain cells. We took advantage of cultured neurons to investigate the role of neuronal adenosine receptors in the control of neurotoxicity caused by kainate and ...

journal_title：Neurochemistry international

authors： Rebola N,Rodrigues RJ,Oliveira CR,Cunha RA

更新日期：2005-10-01 00:00:00

abstract：:The effects of mechanoreceptor stimulation and subsequent ATP release in cyclophosphamide evoked chronic bladder inflammation was examined to demonstrate: (1) whether inflammation modulates ATP release from bladder urothelium and (2) whether intravesical botulinum toxin A administration inhibits urothelial ATP release...

journal_title：Neurochemistry international

authors： Smith CP,Vemulakonda VM,Kiss S,Boone TB,Somogyi GT

更新日期：2005-09-01 00:00:00

abstract：:Inositol 1,4,5-trisphosphate (IP(3)) receptors belong to the intracellular calcium channels that release calcium from the intracellular stores after binding IP(3). Three types of IP(3) receptors occurred in a tissue specific manner and different promoters direct their gene expression. Thus, understanding of the transc...

journal_title：Neurochemistry international

authors： Stefanik P,Macejova D,Mravec B,Brtko J,Krizanova O

更新日期：2005-06-01 00:00:00

abstract：:Although many studies have revealed alterations in neurotransmission during ischaemia, few works have been devoted to the neurochemical effects of mild hypoxia, a situation encountered during life in altitude or in several pathologies. In that context, the present work was undertaken to determine the in vivo mechanism...

journal_title：Neurochemistry international

authors： Orset C,Parrot S,Sauvinet V,Cottet-Emard JM,Bérod A,Pequignot JM,Denoroy L

更新日期：2005-06-01 00:00:00

abstract：:Mecamylamine is a well-described non specific antagonist of nicotinic acetylcholine receptors (nAChRs), used in therapy and in psychopharmacological studies. [(11)C]-Mecamylamine was prepared and evaluated as a putative radioligand for positron emission tomography to study nicotinic acetylcholine receptors. The radios...

journal_title：Neurochemistry international

authors： Sobrio F,Debruyne D,Dhilly M,Chazalviel L,Camsonne R,Kakiuchi T,Tsukada H,Barré L

更新日期：2005-05-01 00:00:00

abstract：:Choline acetyltransferase (ChAT), the synthesizing enzyme for acetylcholine, has been implicated to involve multiple isoforms of ChAT mRNA in several animals. Since these isoforms are mostly non-coding splice variants, only a homologous ChAT protein of about 68 kDa has been shown to be produced in vivo. Recent evidenc...

journal_title：Neurochemistry international

authors： Matsuo A,Bellier JP,Hisano T,Aimi Y,Yasuhara O,Tooyama I,Saito N,Kimura H

更新日期：2005-04-01 00:00:00

abstract：:A decrease in the osmolarity of incubation medium is accompanied by calcium influx in neuronal presynaptic endings. We studied the influence of Ca2+ on exocytosis induced by hypotonic shock using the hydrophilic fluorescent dye acridine orange and the hydrophobic fluorescent dye FM2-10. It was shown using acridine ora...

journal_title：Neurochemistry international

authors： Waseem TV,Rakovich AA,Lavrukevich TV,Konev SV,Fedorovich SV

更新日期：2005-02-01 00:00:00

abstract：:Previously, we revealed that the state of the actin cytoskeleton affects the uptake activity of the serotonin transporter (SERT). Recently, it was reported that the C-terminus of SERT interacts with MacMARCKS, a substrate of PKC that can bind to the actin cytoskeleton. To elucidate the importance of the C-terminal reg...

journal_title：Neurochemistry international

authors： Mochizuki H,Amano T,Seki T,Matsubayashi H,Mitsuhata C,Morita K,Kitayama S,Dohi T,Mishima HK,Sakai N

更新日期：2005-01-01 00:00:00

abstract：:Toluene is a commonly abused solvent found in many industrial and commercial products. The neurobiological effects of toluene remain unclear, but many of them, like those of ethanol, may be mediated by gamma-aminobutyric acid (GABA) and glutamate receptors. Chronic ethanol administration has been shown to alter levels...

journal_title：Neurochemistry international

authors： Williams JM,Stafford D,Steketee JD

更新日期：2005-01-01 00:00:00

abstract：:A competitive RT-PCR assay was used to quantify the expression of the GABA(A) receptor beta(1), beta(2) and beta(3) isoform mRNA transcripts in the superior frontal cortex and motor cortex of 21 control and 22 alcoholic cases. A single set of primers was designed that permitted amplification of all three transcripts a...

journal_title：Neurochemistry international

authors： Buckley ST,Dodd PR

更新日期：2004-12-01 00:00:00

abstract：:Homozygous deletion or mutation in the survival motor neuron (SMN)1 gene causes proximal spinal muscular atrophy (SMA), whereas SMN2 acts as a modifying gene that can influence the severity of SMA. It has been suggested that restoration of the SMN protein level in neuronal cells may prevent cell loss and may be helpfu...

journal_title：Neurochemistry international

authors： Chang HC,Hung WC,Chuang YJ,Jong YJ

更新日期：2004-12-01 00:00:00

abstract：:Phosphodiesterase-5 (PDE5) inhibitors act by competing with the substrate, cGMP, for the catalytic site of the enzyme. Two commercialized PDE5 inhibitors, sildenafil and vardenafil, are being used to treat erectile dysfunction. These two compounds differ in the heterocyclic ring system used to mimic the purine ring of...

journal_title：Neurochemistry international

authors： Corbin JD,Beasley A,Blount MA,Francis SH

更新日期：2004-11-01 00:00:00

abstract：:Soluble guanylyl cyclase (sGC) is a key enzyme of the NO-cGMP pathway which is believed to mediate vasoprotective actions. In cardiovascular diseases such as hypercholesterolemia and atherosclerosis, these important functions of the vascular endothelium are strongly impaired. One of the major reasons for this so-calle...

journal_title：Neurochemistry international

authors： Francois M,Kojda G

更新日期：2004-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia, accounting for 60-70% of cases in subjects over 65 years of age. Several postulates have been put forward that relate AD neuropathology to intellectual and functional impairment. These range from free-radical-induced damage, through cholinergic dysfunction,...

journal_title：Neurochemistry international

authors： Hynd MR,Scott HL,Dodd PR

更新日期：2004-10-01 00:00:00

abstract：:It was previously reported that the K+-evoked release of somatostatin-like immunoreactivity (SRIF-LI) and of cholecystokinin-like immunoreactivity (CCK-LI) from superfused rat cerebrocortical synaptosomes can be enhanced by NMDA or D-serine alone. We here studied the effects of extraterminal pH changes on SRIF-LI and ...

journal_title：Neurochemistry international

authors： Gemignani A,Paudice P,Longordo F,Raiteri M

更新日期：2004-10-01 00:00:00

abstract：:Gliotoxin (GT) is a hydrophobic fungal metabolite of the epipolythiodioxopiperazine group which reacts with membrane thiols. When added to a suspension of energized brain mitochondria, it induces matrix swelling of low amplitude, collapse of membrane potential (DeltaPsi), and efflux of endogenous cations such as Ca2+ ...

journal_title：Neurochemistry international

authors： Salvi M,Bozac A,Toninello A

更新日期：2004-10-01 00:00:00

abstract：:Classical synaptic functions are important and suitable to relatively fast and discretely localized processes, but the nonclassical receptorial functions may be providing revolutionary possibilities for dealing at the cellular level with many of the more interesting and seemingly intractable features of neural and cer...

journal_title：Neurochemistry international

authors： Vizi ES,Kiss JP,Lendvai B

更新日期：2004-09-01 00:00:00

abstract：:Five glutamate transporter genes have been identified; two of these (EAAT3 and EAAT4) are expressed in neurons and are predominantly confined to the membranes of cell bodies and dendrites. At an ultrastructural level, glutamate transporters have been shown to surround excitatory synapses in hippocampus and cerebellum ...

journal_title：Neurochemistry international

authors： Otis TS,Brasnjo G,Dzubay JA,Pratap M

更新日期：2004-09-01 00:00:00

abstract：:To clarify molecular mechanism for sustained activation of gamma protein kinase C (gammaPKC), a neuron-specific subtype, we investigated the involvement of phospholipase A2 (PLA2) products in the membrane association of gammaPKC upon activation of G protein coupled purinoceptors in CHO-K1 and NG 108-15 cells. In addit...

journal_title：Neurochemistry international

authors： Yagi K,Shirai Y,Hirai M,Sakai N,Saito N

更新日期：2004-07-01 00:00:00

abstract：:The presence of acetylcholinesterase (AChE) mRNA and activity in the tissues and cells involved in immune responses prompted us to investigate the level and pattern of AChE components in spleen. AChE activity was higher in mouse spleen (0.46 +/- 0.13 micromol of acetylthiocholine split per hour and per mg protein) tha...

journal_title：Neurochemistry international

authors： Nieto-Cerón S,Moral-Naranjo MT,Muñoz-Delgado E,Vidal CJ,Campoy FJ

更新日期：2004-07-01 00:00:00

abstract：:Astrocytes, besides supporting metabolic and scaffolding functions, play a prominent role in the modulation of neuronal communication. In particular, they are responsible for clearing synaptically-released glutamate via highly specific transporters located on their plasma membrane. Since glutamate is the main excitato...

journal_title：Neurochemistry international

authors： Piet R,Poulain DA,Oliet SH

更新日期：2004-07-01 00:00:00